N,O-Bis(trimethylsilyl)acetamide

Technical Data

Application

• The trimethylsilyl group is a frequently utilized monofunctional blocking group for protic organic and inorganic materials.

• As the product eliminated during the silylation is neutral acetamide, VANABIO® SS5612 can be preferably used for substrates which are acid- or base-sensitive.

• VANABIO® SS5612 can be used for blocking and protection of hydroxyl groups in natural products, e.g. amino acids, carbohydrates

  
  

• VANABIO® SS5612 special silane can be used for blocking and protection of functional groups in organic intermediates.

• The silylated derivatives show improved chemical stability than the original compounds and allow chemical reactions which otherwise would not be possible.

• VANABIO® SS5612 can be used for formation of derivatives of H-acid compounds for analysis

• The silylated derivatives are volatile and can therefore be determined by gas chromatography

• Deblocking is preferably carried out by means of hydrolysis, giving high yields. In some cases, thermal elimination of the trimethylsilyl group is possible.

Packing and Storage

• VANABIO® SS5612 by VANABIO, a reliable silane mamufacturer, is supplied in 160Kg steel drum.

• In the unopened original container VANABIO® SS5612 has a shelf life of one year in a dry and cool place.