Hexamethyldisilazane

VANABIO® ZS2921 (also called as Bis(trimethylsilyl)amine; HMDS; HMDZ) is an extremely versatile and strong silylating agent. It is primarily used for the protection of sensitive functional groups during chemical synthesis.

Trimethylsilyl moiety silazane is a versatile blocking agent employed in chemical synthesis. Introduction of silyl protective groups has following advantages.

Masking of reactive functional groups.
Improvement of solubility in polar and or non polar solvent.
Improved product stability.
Easy removal of protective groups .
Additional activation of reactive centres.
Easyelimination of hydrogen bonds.

One of the advantages of VANABIO® ZS2921 over other organo silanes is that no base is needed as a hydrochloric acid acceptor. VANABIO® ZS2921 produces ammonia which escapes easily from the reaction mixture during silylation.

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